Wake Up Call (1) 4400
新一季《4400》承接上一季劇情，講述四千四百人被不明飛行物帶走，事隔一年後，Tom回到國家技術援助中心，被指派做文書的工作，拍擋Diana與多位無能的搭檔合作後，最終找到讓Tom重回崗位的辦法。另一方面，Richard與Lily發現，他們六個月大的孩子有極強的神秘力量，甚至能操縱其他人的思想，以及令人產生幻覺而自殺身亡，令Richard感到危機重重……
第一集講述Tom和Diana在海灘揭開了4,400人五十年來秘密的一年後，Tom儘管立了功，還是因為不聽從命令而被罰在辦公室當文書。Tom的兒子Kyle一直都在NTAC的監控檢查，經歷了多次的測試與實驗後，仍沒有任何新的發現。
Tom的老拍檔Diana懇求NTAC太平洋西北分部的新上司Nina恢復Tom的職位，她還收養了Maia，但是卻沒有注意到Maia擁有預知未來的超能力……
NTAC agent Tom Baldwin has been riding a desk job for the past twelve months, penance for his acts of insubordination, despite the fact that they were key in unlocking the mystery behind the 4400. Kyle, Tom's son, has been living under observation at NTAC, where he has endured numerous tests, revealing no new information. Diana Skouris, Tom's partner, appeals to Nina Jarvis, the new head of the Pacific Northwest Division of NTAC, to reinstate Tom in the field. On a personal note, Diana has adopted Maia Rutledge as her daughter, unaware that the girl still has precognitive insights. Meanwhile, Richard, Lily and their baby Isabelle, now six months old, are living in a mountain cabin hiding from Jordan Collier and NTAC. Collier has become the self-proclaimed figurehead of the 4400 and is on the verge of opening the first “4400 Center,” a place not only for fellow returnees, but regular everyday people looking to “unlock” the 4400 within themselves. And Shawn Farrell has left his family behind to become Collier's protégé, using his healing ability to bring in big money contributors to the center
