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by H. Hunter Handsfield, M.D., Nov 25, 2011
4) Yes.  All results below the cut-off are truly negative.  There is no difference, for example, between ELISA values of, say, 0.3 and 0.85.

5) You are correct that most false positive results are in the gray range.  Official interpretation of the commonly markted HSV-2 tests (incluidng HerpeSelect) is that any value over 1.1 is positive.  (0.9 to 1.1 is officially equivocal.)  However, the likelihood of a true positive result rises with increasing numerical values.  Probably only 10-20% of values of 1.2 are truly positive; around 50% of those at 2.0; and it's only values of 3.5 and higher that are definitely positive.

Here is a thread that explains why there is a difference between the official cut-off values (according to the test manufacturer) and the reliable results according to herpes experts:  http://www.medhelp.org/posts/STDs/IGG-Test-Result-Confusion/show/593272




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